Official filing Q&A | Full version safety evaluation and preservative challenge topic for cosmetics 2
Q&A on the Filing of Ordinary Cosmetics by Guangzhou Municipal Supervision Bureau 67th issue
Guidelines for Testing and Evaluation Techniques of Cosmetics Anti corrosion Challenge Why is it recommended to useCMCCStrain of bacteria
Guidelines for Testing and Evaluation Techniques of Cosmetics Anti corrosion Challenge hereinafter referred to as Technical Guidelines recommendCMCCStrain as test strain,Mainly based on the simplicity of the purchasing process and the easy availability of bacterial strains.ATCCAlthough the strain originated from the Global Center for Biological Resources,But the price is high,The purchasing process is complex.Users are making purchasesATCCStrain time,Need to provide a commitment letter included application Unit Introduction Biosafety Certificate Multiple materials including product transfer agreement and business license,And accept the supervision and inspection of Chinese customs.These requirements apply to the majority of cosmetics registrants in China For the registrant,Undoubtedly, it has increased the difficulty significantly,Resulting in many cosmetics registrants The registrant finds it difficult to obtain information from formal and legal channels.in addition,ATCCThe transportation cycle of bacterial strains is long,May bring uncertainty to the experiment.by comparison,CMCCStrain as the standard strain in China,Relatively cheap in price and easy to obtain,At the same time, its purchasing process is relatively simple,As a cosmetic registrant The registrant saved a lot of time and costs,More suitable for anti-corrosion challenge testing.
Cosmetic registrant Can the registrant choose other methods for evaluating the anti-corrosion challenge test
book Technical Guidelines As a non mandatory reference document,Its main purpose is for cosmetic registrants The registrant provides guidance and suggestions when conducting relevant tests.Cosmetic registrant The registrant can choose based on their actual needs and circumstances,Select industry standards international standard asISO 11930 Or self built methods,Comprehensively evaluate the effectiveness of the product's anti-corrosion system.
If the product is selected from the appendixA.6～A.9of4Neutralizing agent,But the verification results show that these neutralizing agents still cannot effectively neutralize certain strains of bacteria,What methods should be taken to solve it
appendixA.6～A.9In the middle4Neutralizing agents are only recommended for use,Cosmetic registrant The registrant may choose the appropriate neutralizing agent based on the actual product formula.
Technical Guidelines Can we increase the method of mixed infection bacterial inoculation in China
Mixed bacterial inoculation may lead to differences in experimental results compared to single bacterial inoculation,Increasing the complexity and uncertainty of result evaluation.Considering the consistency and reproducibility of the experimental results,And follow the recommended practices of international standards, Technical Guidelines The method of mixed infection inoculation has not been adopted in China.For products with the same anti-corrosion system and similar formulas,What are the evaluation requirements for the anti-corrosion challenge test
For products with the same anti-corrosion system and similar formulas,The effectiveness of the product's anti-corrosion system can be evaluated by referring to existing materials and experimental data,Formulate an anti-corrosion challenge evaluation report,And submit explanatory materials for its anti-corrosion system and formula system.
